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Clinical Chemistry 35: 130-134, 1989;
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Clinical Chemistry, Vol 35, 130-134, Copyright © 1989 by American Association for Clinical Chemistry

Clinical and analytical evaluation of different methods for measurement of creatine kinase isoenzyme MB

JG Schwartz, RW Brown, CA McMahan, CL Gage and SA Herber
Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7750.

We evaluated the clinical and analytical performance of the new immunochemiluminometric assay (ICMA; Ciba Corning) for measurement of creatine kinase isoenzyme MB (CK-MB), and compared it with three other methods: immunoradiometric assay (IRMA; International Immunoassay Labs); immunoinhibition assay (Seradyn); and an immunoinhibition/column method (Du Pont). Intra-test precision for all kits was good. We evaluated 32 patients' samples by all four methodologies. Only one of the four methods (aca, Du Pont) showed evidence of linearity. Efficiency in the diagnosis of myocardial injury in our study ranged from 53% (Seradyn) to 96% (Du Pont). We evaluated serial specimens from 20 separate patients by the IRMA and the ICMA to determine whether myocardial injury could be diagnosed earlier by the ICMA. In patients with acute myocardial infarction, the ICMA displayed positive values earlier and longer than the IRMA, suggesting that the ICMA is suited for screening for myocardial damage in hospitalized patients.


The following articles in journals at HighWire Press have cited this article:


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 ANGIOLOGYHome page
P. C. Painter, S. Van Meter, R. L. Dabbs, and G. E. Clement
Analytical Evaluation and Comparison of Dupont aca(R) Lactate Dehydrogenase-1 (LD1) Isoenzyme Assay Diagnostic Efficiency for Acute Myocardial Infarction Detection with Other LD1 Methods and aca@ CK-MB: A Two-Site Study
Angiology, July 1, 1994; 45(7): 585 - 595.
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Copyright © 1989 by the American Association for Clinical Chemistry.