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Clinical Chemistry 35: 134-138, 1989;
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Clinical Chemistry, Vol 35, 134-138, Copyright © 1989 by American Association for Clinical Chemistry

Effects of various serum proteins on quantification of fructosamine

S Rodriguez-Segade, S Lojo, MF Camina, JM Paz and R Del Rio
Department of Biochemistry, Hospital General de Galicia, Faculty of Medicine, University of Santiago de Compostela, Spain.

We determined fructosamine concentrations with the CentrifiChem 600 centrifugal analyzer and the Hitachi 737 discrete analyzer. Reference intervals agreed with the most recently published results, and values in fasting patients were significantly correlated with glycated hemoglobin, plasma glucose, albumin, beta- and gamma-globulins, IgG, IgA, IgM, and total protein. Partial correlation analysis showed that only fructosamine and IgA were dependently related. In a group of nondiabetic patients with pathological values for IgA concentrations, 79.4% had pathological values for fructosamine. These results throw doubt on the clinical value of fructosamine determinations if serum IgA is not taken into account.


The following articles in journals at HighWire Press have cited this article:


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 Clin. Chem.Home page
K. Fujita, L. K. Curtiss, I. Sakurabayashi, F. Kameko, N. Okumura, F. Terasawa, M. Tozuka, and T. Katsuyama
Identification and Properties of Glycated Monoclonal IgA That Affect the Fructosamine Assay
Clin. Chem., May 1, 2003; 49(5): 805 - 808.
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Copyright © 1989 by the American Association for Clinical Chemistry.