Clinical Chemistry
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Clinical Chemistry 35: 2118-2120, 1989;
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Clinical Chemistry, Vol 35, 2118-2120, Copyright © 1989 by American Association for Clinical Chemistry

Multi-factor designs. II. A design for identifying instruments with sample-to-sample carryover and drift

B Schlain and JS Krouwer
Ciba Corning Diagnostics Corp., Medfield, MA 02052.

We describe a nearly orthogonal two-level design that involves use of a weighted analysis to estimate drift and very low amounts of sample-to- sample carryover simultaneously. Identifying systematic errors from these sources is especially important for assays of analytes presenting a large range and with a medical decision point close to zero. The design is illustrated with data for thyrotropin, where, in one run with 32 samples, 0.08% carryover was detected in the presence of concentration-dependent negative drift.




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Copyright © 1989 by the American Association for Clinical Chemistry.