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Clinical Chemistry 35: 2241-2243, 1989;
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Clinical Chemistry, Vol 35, 2241-2243, Copyright © 1989 by American Association for Clinical Chemistry

Comparative results with five cannabinoid immunoassay systems at the screening threshold of 100 micrograms/L

DJ Wells and MT Barnhill Jr
Department of Pathology, University of South Alabama Medical Center, Mobile 36617.

Five commercially available immunoassay techniques were compared for the detection of cannabinoid metabolites in urine at a positive cutoff of 100 micrograms/L. Numerical values, available for four of these techniques, were used to evaluate inter-assay equivalence at this threshold. The total number of positive results differed for each assay, with some individual samples exhibiting wide variations in numerical values. As a group, the radioimmunoassay systems gave a greater proportion of positive specimens than did enzyme-linked or fluorescence-polarization-based techniques. The single threshold of detection suggested by federal guidelines does not provide for equivalent screening of cannabinoids with these immunoassay techniques.




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Copyright © 1989 by the American Association for Clinical Chemistry.