Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 35: 2326-2330, 1989;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Van Lente, F.
Right arrow Articles by Suit, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Van Lente, F.
Right arrow Articles by Suit, P.

Clinical Chemistry, Vol 35, 2326-2330, Copyright © 1989 by American Association for Clinical Chemistry

Assessment of renal function by serum creatinine and creatinine clearance: glomerular filtration rate estimated by four procedures

F Van Lente and P Suit
Department of Biochemistry, Cleveland Clinic Foundation, OH 44195.

We compared creatinine concentrations in serum and urine and creatinine clearances determined by two Jaffe (Beckman's "Astra," Boehringer Mannheim Diagnostics) and two enzymatic (Kodak, Boehringer Mannheim Diagnostics) methods. Serum creatinine and creatinine clearances determined by each method were also compared with the glomerular filtration rate as measured with use of sodium [125I]iothalamate in patients with a wide range of renal function. Results between methods correlated excellently, but we saw clear method-dependent biases of up to 2.9 mg/L for serum. The highest serum creatinine values and the lowest creatinine clearances were obtained with Boehringer Mannheim Diagnostics' Jaffe method. The reciprocal of the serum creatinine and the creatinine clearance also correlated well with the glomerular filtration rate, but all methods over-estimated the glomerular filtration rates to varying degrees. Appropriate standardization of methods appears to be as important as method principle for establishing an accurate relationship between creatinine determinations and glomerular filtration rate.


The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Cancer Res.Home page
M. Ando, H. Minami, Y. Ando, H. Saka, S. Sakai, M. Yamamoto, Y. Sasaki, K. Shimokata, and Y. Hasegawa
Multi-Institutional Validation Study of Carboplatin Dosing Formula Using Adjusted Serum Creatinine Level
Clin. Cancer Res., December 1, 2000; 6(12): 4733 - 4738.
[Abstract] [Full Text]

Home page
 ANN INTERN MEDHome page
A. S. Levey, J. P. Bosch, J. B. Lewis, T. Greene, N. Rogers, D. Roth, and for the Modification of Diet in Renal Disease Stud
A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation
Ann Intern Med, March 16, 1999; 130(6): 461 - 470.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1989 by the American Association for Clinical Chemistry.