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Clinical Chemistry 35: 238-240, 1989;
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Clinical Chemistry, Vol 35, 238-240, Copyright © 1989 by American Association for Clinical Chemistry

Relative importance of estrogen and progesterone receptor assays as prognostic indicators in primary breast cancer: a short-term study

D Brocklehurst, CE Wilde, JA Finbow, R Brett, AE Champion and DG Dewhurst
Department of Clinical Chemistry, Doncaster Royal Infirmary, U.K.

This short-term study of the relative importance of estrogen and progesterone receptors shows that progesterone receptor correlates better than estrogen receptor with tumor recurrence regardless of lymph- node status. Life-table analysis has effectively identified only two groups of patients that may be classified by progesterone receptor status alone. Progesterone-receptor negativity correlated well with tumors of histological Grade III; estrogen-receptor positivity correlated with Grade I and II tumors. The earlier recurrence of Grade III breast tumors may explain why progesterone receptor is a better prognostic indicator than estrogen receptor in short-term studies.


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Neopterin Is an Independent Prognostic Variable in Females with Breast Cancer
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