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Clinical Chemistry, Vol 35, 271-274, Copyright © 1989 by American Association for Clinical Chemistry
LH Bernstein, CJ Leukhardt-Fairfield, W Pleban and R Rudolph
Department of Pathology, Bridgeport Hospital, CT 06110.
In this ongoing study, albumin and prealbumin (transthyretin) changes were compared in 40 patients managed with enteral and (or) parental support with attainment of caloric/protein goals. The concentration of prealbumin in serum changed rapidly and more accurately reflected current nutritional status of these patients than did that of albumin. We determined concentrations of albumin and prealbumin that reflected significant improvement in nutritional status, using Rudolph's approach based on Shannon information measures. Reference values for albumin and prealbumin in the treatment populations were 25 g/L and 107 mg/L, respectively. A prealbumin concentration of 135 mg/L or greater reflected a return to stable status.
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