Clinical Chemistry
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Clinical Chemistry 35: 275-278, 1989;
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Clinical Chemistry, Vol 35, 275-278, Copyright © 1989 by American Association for Clinical Chemistry

A longitudinal study of thyroid function in pregnancy

A Price, H Griffiths and BW Morris
Department of Clinical Chemistry, Northern General Hospital, Sheffield, U.K.

We undertook a prospective longitudinal study of thyroid function in 36 pregnant women. There were significant increases in thyroxin-binding globulin, thyrotropin, and triiodothyronine. Albumin, free thyroxin (measured by an analog and a nonanalog method), and the free thyroxin index were significantly decreased. Results for the free thyroxin methods were correlated with each other in each trimester. We could find no evidence for artifacts related to albumin or thyroxin-binding globulin with either method for free thyroxin.


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 Endocr. Rev.Home page
D. Glinoer
The Regulation of Thyroid Function in Pregnancy: Pathways of Endocrine Adaptation from Physiology to Pathology
Endocr. Rev., June 1, 1997; 18(3): 404 - 433.
[Abstract] [Full Text]


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