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Clinical Chemistry 35: 298-301, 1989;
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Clinical Chemistry, Vol 35, 298-301, Copyright © 1989 by American Association for Clinical Chemistry

Simultaneous determination of pentoxifylline and three metabolites in biological fluids by liquid chromatography

WE Lambert, MA Yousouf, BM Van Liedekerke, JE De Roose and AP De Leenheer
Laboratoria voor Medische Biochemie en voor Klinische Analyse, Gent, Belgium.

We describe a sensitive and specific liquid-chromatographic assay for pentoxifylline and three of its metabolites in human plasma and urine. Addition of hydrochloric acid to the sample before extraction, and incorporation of acetic acid in the chromatographic eluent, allow the simultaneous determination of the four compounds plus an internal standard in one chromatographic run. Unlike gas-chromatographic procedures, this method does not involve derivatization no similar analysis of serum or plasma samples has been described before now. The method has been applied successfully to routine analysis and to pharmacokinetic studies.


The following articles in journals at HighWire Press have cited this article:


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 J. Pharmacol. Exp. Ther.Home page
Z. M. N. Quezado, W. D. Hoffman, S. M. Banks, R. L. Danner, P. Q. Eichacker, G. M. Susla, and C. Natanson
Increasing Doses of Pentoxifylline as a Continuous Infusion in Canine Septic Shock
J. Pharmacol. Exp. Ther., January 1, 1999; 288(1): 107 - 113.
[Abstract] [Full Text]


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Copyright © 1989 by the American Association for Clinical Chemistry.