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Clinical Chemistry 35: 312-314, 1989;
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Clinical Chemistry, Vol 35, 312-314, Copyright © 1989 by American Association for Clinical Chemistry

Assessment of renal function by inulin clearance: comparison with creatinine clearance as determined by enzymatic methods

FS Apple, P Benson, PA Abraham, TG Rosano and CE Halstenson
Hennepin County Medical Center, Minneapolis, MN 55415.

We compared creatinine clearances determined by enzymatic (Kodak Ektachem 700 single-slide, Boehringer Mannheim creatinine PAP) and nonenzymatic (Jaffe, HPLC) methods with glomerular filtration rate measured by inulin clearance in patients with varying degrees of renal function. The Kodak enzymatic assay gave values for creatinine 2 to 3 mg/L higher than the other methods. This resulted in significantly lower creatinine clearances than inulin clearances and creatinine clearances determined by the other methods. However, correlations between all methods for serum and urinary creatinine values and clearances were good. To avoid between assay (enzymatic vs nonenzymatic) discrepancies, manufacturers should agree to an acceptable standard of calibration under the usual conditions used with patients.




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Copyright © 1989 by the American Association for Clinical Chemistry.