| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Chemistry, Vol 35, 369-373, Copyright © 1989 by American Association for Clinical Chemistry
SK Gallagher, LK Johnson and DB Milne
USDA, ARS, Human Nutrition Research Center, Grand Forks, ND 58202.
Five free-living women (ages 28-38 y) and five women (ages 23-44 y) residing in a metabolic unit and eating a constant diet were assessed for variation in indices related to mineral nutrition. Blood was sampled once a month for five months, once a week for five weeks, and once a day for five days to assess analytical and biological variability. Analytical variability was determined by using concurrently run duplicate control samples prepared from plasma or serum pools. Of the measured indices, serum ferritin varied most, with intra-individual variance of 4.72% to 18.0%. Much of this variance may have been because of changes in iron status or in the analytical technique used. Intra-individual month-to-month variance for other indices ranged from 17% for superoxide dismutase (EC 1.15.1.1) to 1.5% for calcium. Correction for long-term analytical variation indicated that most of the variance was associated with the biological component. The higher biological variabilities of some indices, including ferritin or superoxide dismutase, need to be considered when nutritional status is being evaluated or when serial observations are made over a protracted period in clinical studies or trials.
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  J. Arnaud, J.-P. Weber, C. W. Weykamp, P. J. Parsons, J. Angerer, E. Mairiaux, O. Mazarrasa, S. Valkonen, A. Menditto, M. Patriarca, et al. Quality Specifications for the Determination of Copper, Zinc, and Selenium in Human Serum or Plasma: Evaluation of an Approach Based on Biological and Analytical Variation Clin. Chem., November 1, 2008; 54(11): 1892 - 1899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D Hunt and L. K Johnson Calcium requirements: new estimations for men and women by cross-sectional statistical analyses of calcium balance data from metabolic studies Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1054 - 1063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D Hunt and L. K Johnson Magnesium requirements: new estimations for men and women by cross-sectional statistical analyses of metabolic magnesium balance data. Am. J. Clinical Nutrition, October 1, 2006; 84(4): 843 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R Hunt and Z. K Roughead Nonheme-iron absorption, fecal ferritin excretion, and blood indexes of iron status in women consuming controlled lactoovovegetarian diets for 8 wk Am. J. Clinical Nutrition, May 1, 1999; 69(5): 944 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. G. Schlagheck, J. M. Kesler, M. B. Jones, N. L. Zorich,, L. D. Dugan, M. H. Davidson, and J. C. Peters Olestra's Effect on Vitamins D and E in Humans Can Be Offset by Increasing Dietary Levels of These Vitamins J. Nutr., August 1, 1997; 127(8): 1666 - 1666. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
