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Clinical Chemistry 35: 560-563, 1989;
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Clinical Chemistry, Vol 35, 560-563, Copyright © 1989 by American Association for Clinical Chemistry

Biological variation of urinary N-acetyl-beta-D-glucosaminidase: practical and clinical implications

I Stolarek, JE Howey and CG Fraser
Department of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.

The analytical, within-subject, and between-subject components of variation of N-acetyl-beta-D-glucosaminidase (NAG) were estimated from duplicate assays of 10 timed first morning and 10 untimed urine specimens collected from each of 15 ostensibly healthy individuals. Results were expressed in terms of activity, NAG/creatinine ratio, and excretion rate. Current analytical methods can achieve desirable performance standards. NAG has little individuality, and conventional population-based reference intervals are therefore useful. In view of the practicability and relatively low within-subject variation, for routine clinical purposes we prefer assay of NAG in first morning urine, expressing the results in terms of activity. Using the results of assays of different specimens, we found that the correlation between urinary albumin and NAG varied considerably, owing to the large intrinsic variability of both analytes; this might explain previous conflicting results.


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Carcinogenesis, July 1, 1999; 20(7): 1247 - 1252.
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Copyright © 1989 by the American Association for Clinical Chemistry.