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Clinical Chemistry 35: 564-568, 1989;
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Clinical Chemistry, Vol 35, 564-568, Copyright © 1989 by American Association for Clinical Chemistry

Cyclosporine concentrations in blood after liver transplantation: correlation of immunoassay results with clinical events [published erratum appears in Clin Chem 1989 Nov;35(11):2257]

MC Haven, LM Sobeski, RA Earl and RS Markin
Department of Pathology, and Microbiology, University of Nebraska Medical Center, Omaha 68105.

To investigate the clinical utility of immunoassays for cyclosporine and metabolites in plasma and whole blood, we monitored 25 patients after orthotopic liver transplantation. We compared cyclosporine as measured by TDx fluorescence polarization immunoassay (of both plasma and whole blood) and by two polyclonal radioimmunoassays (from Sandoz and INCSTAR). We found considerable differences in measured cyclosporine concentrations, which were dependent on method, matrix, and clinical condition. Correlation coefficients between results by the various methods for samples from individual patients ranged from 0.825 to 0.996. The three methods used for monitoring cyclosporine in whole blood gave proportional results (Sandoz less than INCSTAR less than TDx) in individual patients, but results for the two methods for plasma sometimes differed by more than 100%. In some cases, ratios of plasma cyclosporine concentration (result by TDx/result by Sandoz) were correlated with disturbances in hepatic excretory function or kidney function. This ratio may be useful in monitoring for nephrotoxicity.


The following articles in journals at HighWire Press have cited this article:


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 Journal of Pharmacy PracticeHome page
H. G. McCoy and K. R. Labrosse
State of the Art: Measurement of Drug Concentrations for Therapeutic Drug Monitoring
Journal of Pharmacy Practice, January 1, 1989; 2(6): 335 - 346.
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Copyright © 1989 by the American Association for Clinical Chemistry.