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Clinical Chemistry 35: 612-616, 1989;
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Clinical Chemistry, Vol 35, 612-616, Copyright © 1989 by American Association for Clinical Chemistry

Characterization of amniotic fluid lamellar bodies by resistive-pulse counting: relationship to measures of fetal lung maturity

SB Dubin
Department of Pathology, Cedars-Sinai Medical Center, Los Angeles 90048.

Resistive-pulse counting studies of amniotic fluid lamellar bodies are presented and demonstrate a strong concordance with the predictions of accepted measures of fetal lung maturity. Uncentrifuged as well as centrifuged specimens could be evaluated, because cells and debris are rejected electronically. The technique is not affected by bilirubin or debris of lysed whole blood, and only mildly by meconium. Lamellar body number density and mean lamellar body volume were determined for 161 uncentrifuged and 241 centrifuged specimens. Number density maturity criteria (40,000/microL and 26,000/microL, respectively) were shown to be highly concordant with established measures of fetal lung maturity; mean lamellar body volume did not extend this concordance. Since electronic cell counters are generally available 24 h per day and the approach requires neither centrifugation nor subjective interpretation and is rapid and inexpensive, it is proposed that determining lamellar body number density by resistive-pulse counting may be a useful initial screen for the assessment of fetal lung maturity.


The following articles in journals at HighWire Press have cited this article:


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A. Szallasi, A. M. Gronowski, and C. S. Eby
Lamellar Body Count in Amniotic Fluid: A Comparative Study of Four Different Hematology Analyzers
Clin. Chem., June 1, 2003; 49(6): 994 - 997.
[Full Text] [PDF]

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 Obstet GynecolHome page
M. G. NEERHOF, E. I. HANEY, R. K. SILVER, E. R. ASHWOOD, I.-S. LEE, and J. J. PIAZZE
Lamellar Body Counts Compared With Traditional Phospholipid Analysis as an Assay for Evaluating Fetal Lung Maturity
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 Obstet GynecolHome page
M. G. Neerhof, J. C. Dohnal, E. R. Ashwood, I.-S. Lee, and M. M. Anceschi
LAMELLAR BODY COUNTS: A CONSENSUS ON PROTOCOL
Obstet. Gynecol., February 1, 2001; 97(2): 318 - 320.
[Abstract] [Full Text] [PDF]

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 Obstet GynecolHome page
P. S. LEWIS, M. R. LAURIA, J. DZIECZKOWSKI, G. O. UTTER, and M. P. DOMBROWSKI
Amniotic Fluid Lamellar Body Count: Cost-effective Screening for Fetal Lung Maturity
Obstet. Gynecol., March 1, 1999; 93(3): 387 - 391.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
E. R. Ashwood
Standards of laboratory practice: evaluation of fetal lung maturity
Clin. Chem., January 1, 1997; 43(1): 211 - 214.
[Abstract] [Full Text] [PDF]


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Copyright © 1989 by the American Association for Clinical Chemistry.