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Clinical Chemistry 35: 648-651, 1989;
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Clinical Chemistry, Vol 35, 648-651, Copyright © 1989 by American Association for Clinical Chemistry

Interference of common household chemicals in immunoassay methods for drugs of abuse [published erratum appears in Clin Chem 1989 Nov;35(11):2257]

A Warner
Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, OH 45267-0714.

I report how some adulterants affect results for drugs of abuse in urine as measured by Roche RIA, Syva emit d.a.u., and Abbott TDx fpia (fluorescence polarization immunoassay) for the following drugs: amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, opiates, and phencyclidine (PCP). Sodium chloride interfered negatively with all of these drugs when assayed by emit and caused a slight decrease in measured benzodiazepine concentration by fpia. Drug concentrations were also decreased by added H2O2 (emit: benzodiazepine), Joy detergent (emit: cannabinoid, benzodiazepines, PCP), NaHCO3 (emit: opiate; fpia: PCP), or NaClO [corrected] (emit, RIA, fpia: amphetamines, opiates, PCP; emit, fpia: cannabinoid; emit: benzodiazepines). False-positive results were caused by H2O2 (fpia: benzodiazepines) and Joy (RIA, fpia: benzodiazepine, cannabinoid; fpia: barbiturate, amphetamine). Sodium bicarbonate causes a suspiciously high pH in the urine, NaClO [corrected] an apparently low pH (using pH paper).


The following articles in journals at HighWire Press have cited this article:


Home page
 Journal of Pharmacy PracticeHome page
P. D. Anderson, K. Naik, C. Kinemond, and A. ImObersteg
Forensic Testing for Drugs of Abuse
Journal of Pharmacy Practice, June 1, 2000; 13(3): 226 - 235.
[Abstract] [PDF]

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 Clin. Chem.Home page
D. Ritter, C. M. Cortese, L. C. Edwards, J. L. Barr, H. D. Chung, and C. Long
Interference with testing for lysergic acid diethylamide
Clin. Chem., April 1, 1997; 43(4): 635 - 637.
[Abstract] [Full Text] [PDF]


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Copyright © 1989 by the American Association for Clinical Chemistry.