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Clinical Chemistry 35: 717-720, 1989;
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Clinical Chemistry, Vol 35, 717-720, Copyright © 1989 by American Association for Clinical Chemistry

Modulated adhesion: a proposal for the role of myelin-associated glycoprotein in myelin wrapping

J Attia, M Tropak, PW Johnson, W Newerly-Abranow, T Pawson, JC Roder and RJ Dunn
Department of Medical Genetics, University of Toronto, Ontario, Canada.

Myelin-associated glycoprotein (MAG) is a 100-kDa integral membrane glycoprotein expressed by oligodendrocytes and Schwann cells in the central and peripheral nervous systems, respectively. It is found first in loosely wrapped myelin and then periaxonally after compaction. Clinical findings, structural analysis, and cell assays indicate a role for MAG in adhesion. We propose that the phosphorylation state of MAG modulates its adhesion and that a minimum spatial requirement for the separation of the kinase and phosphatase activities postulated by this model may explain the correlation between axon size and myelination state.




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Copyright © 1989 by the American Association for Clinical Chemistry.