Clinical Chemistry
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Clinical Chemistry 35: 848-851, 1989;
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Clinical Chemistry, Vol 35, 848-851, Copyright © 1989 by American Association for Clinical Chemistry

A simplified and rapid test for acetylator phenotyping by use of the peak height ratio of two urinary caffeine metabolites

A el-Yazigi, K Chaleby and CR Martin
Biological and Medical Research Department, King Faisal Specialist Hospital, Saudi Arabia.

We describe a simplified liquid-chromatographic test in which acetylator phenotype is determined by measuring the peak height ratio of two urinary caffeine metabolites, 5-acetylamino-6-formylamino-3- methyluracil and 1-methylxanthine. We applied this test to determine the acetylator phenotypes of 52 subjects who regularly drink coffee, tea, or caffeinated beverages. Also, we determined the acetylator phenotypes of these subjects according to a well-established sulfasalazine test, which yielded identical results. We established the reproducibility of the described test by determining the acetylator phenotypes of 10 additional subjects on two different days separated by a period of two to five weeks. Of the 52 subjects examined by both tests, 40 (76.9%) were classified as slow acetylators, which agrees well with the percentage reported elsewhere for 297 similar subjects from the Saudi population.




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Copyright © 1989 by the American Association for Clinical Chemistry.