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Clinical Chemistry 35: 1005-1010, 1989;
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Clinical Chemistry, Vol 35, 1005-1010, Copyright © 1989 by American Association for Clinical Chemistry

Multicenter evaluation of TDx test for assessing fetal lung maturity

JC Russell, CM Cooper, CH Ketchum, JS Torday, DK Richardson, JA Holt, LA Kaplan, JR Swanson and WM Ivie
Department 9TP AP20, Abbott Laboratories, Abbott Park, IL 60064.

"TDx Fetal Lung Maturity," an automated assay that measures the relative concentrations of surfactant and albumin in amniotic fluid, was compared with the lecithin/sphingomyelin (L/S) ratio and phosphatidylglycerol determination at five clinical sites. A total of 695 amniotic fluid samples were analyzed, of which 312 were followed by delivery of the infant within three days of sample collection. Of these 312, 24 developed respiratory distress syndrome and seven developed transient tachypnea. With the cutoff for maturity set at a surfactant/albumin value of 50 mg/g, the assay showed a sensitivity of 0.96 and a specificity of 0.88 for all samples, compared with a sensitivity of 0.96 and a specificity of 0.83 for the L/S ratio. The combination of rapid assay (30 min), accurate results, and uniformity among testing centers makes the TDx assay a very promising method.


The following articles in journals at HighWire Press have cited this article:


Home page
 Obstet GynecolHome page
T. S. Albright, D. F. Colombo, E. Euscher, and P. Samuels
Evaluation of the Effect of Meconium on Assessment of Fetal Lung Maturity Status by TDxFLM II Testing
Obstet. Gynecol., November 1, 2004; 104(5): 952 - 956.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
D. G. Grenache, C. A. Parvin, and A. M. Gronowski
Preanalytical Factors That Influence the Abbott TDx Fetal Lung Maturity II Assay
Clin. Chem., June 1, 2003; 49(6): 935 - 939.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
C. R. Fantz, C. Powell, B. Karon, C. A. Parvin, K. Hankins, M. Dayal, Y. Sadovsky, V. Johari, F. S. Apple, and A. M. Gronowski
Assessment of the Diagnostic Accuracy of the TDx-FLM II to Predict Fetal Lung Maturity
Clin. Chem., May 1, 2002; 48(5): 761 - 765.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
R. K. EDWARDS, P. DUFF, and K. C. ROSS
Amniotic Fluid Indices of Fetal Pulmonary Maturity With Preterm Premature Rupture of Membranes
Obstet. Gynecol., July 1, 2000; 96(1): 102 - 105.
[Abstract] [Full Text] [PDF]


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Copyright © 1989 by the American Association for Clinical Chemistry.