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Clinical Chemistry, Vol 35, 1005-1010, Copyright © 1989 by American Association for Clinical Chemistry
JC Russell, CM Cooper, CH Ketchum, JS Torday, DK Richardson, JA Holt, LA Kaplan, JR Swanson and WM Ivie
Department 9TP AP20, Abbott Laboratories, Abbott Park, IL 60064.
"TDx Fetal Lung Maturity," an automated assay that measures the relative concentrations of surfactant and albumin in amniotic fluid, was compared with the lecithin/sphingomyelin (L/S) ratio and phosphatidylglycerol determination at five clinical sites. A total of 695 amniotic fluid samples were analyzed, of which 312 were followed by delivery of the infant within three days of sample collection. Of these 312, 24 developed respiratory distress syndrome and seven developed transient tachypnea. With the cutoff for maturity set at a surfactant/albumin value of 50 mg/g, the assay showed a sensitivity of 0.96 and a specificity of 0.88 for all samples, compared with a sensitivity of 0.96 and a specificity of 0.83 for the L/S ratio. The combination of rapid assay (30 min), accurate results, and uniformity among testing centers makes the TDx assay a very promising method.
The following articles in journals at HighWire Press have cited this article:
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  D. G. Grenache, C. A. Parvin, and A. M. Gronowski Preanalytical Factors That Influence the Abbott TDx Fetal Lung Maturity II Assay Clin. Chem., June 1, 2003; 49(6): 935 - 939. [Abstract] [Full Text] [PDF]
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C. R. Fantz, C. Powell, B. Karon, C. A. Parvin, K. Hankins, M. Dayal, Y. Sadovsky, V. Johari, F. S. Apple, and A. M. Gronowski Assessment of the Diagnostic Accuracy of the TDx-FLM II to Predict Fetal Lung Maturity Clin. Chem., May 1, 2002; 48(5): 761 - 765. [Abstract] [Full Text] [PDF]
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