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Clinical Chemistry 35: 918-921, 1989;
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Clinical Chemistry, Vol 35, 918-921, Copyright © 1989 by American Association for Clinical Chemistry

Bedside diagnosis of alcohol intoxication with a pocket-size breath- alcohol device: sampling from unconscious subjects and specificity for ethanol

M Falkensson, W Jones and B Sorbo
Department of Clinical Chemistry, Faculty of Health Sciences, Linkoping University Hospital, Sweden.

We describe a novel mouth-cup device for sampling breath from unconscious subjects and analysis with a hand-held breath-alcohol instrument, the "Alcolmeter SD-2." This equipment was evaluated in healthy volunteers after they drank a moderate dose of alcohol. Three kinds of breath were analyzed: (a) end-expired air from a conventional mouth-tube, (b) breath sampled from the mouth-cup, and (c) air from a nasal tube supplied with the breath analyzer. The ethanol concentration in breath from the mouth-cup was slightly less than in end-expired air but significantly greater than in nasal air. Results with mouth-tube and mouth-cup correlated highly with blood-ethanol concentration as determined by gas chromatography; nasal-tube air correlated less well. The Alcolmeter responded not only to ethanol but also to methanol, 1- propanol, and 2-propanol, whereas ethylene glycol gave no response. The time-response curve for methanol was different, and this might permit differential diagnosis of methanol poisoning.


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C. DiPadova, R. Roine, M. Frezza, R. T. Gentry, E. Baraona, and C. S. Lieber
Effects of Ranitidine on Blood Alcohol Levels After Ethanol Ingestion: Comparison With Other H2-Receptor Antagonists
JAMA, January 1, 1992; 267(1): 83 - 86.
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Copyright © 1989 by the American Association for Clinical Chemistry.