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Clinical Chemistry 35: 922-925, 1989;
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Clinical Chemistry, Vol 35, 922-925, Copyright © 1989 by American Association for Clinical Chemistry

Correlation of HbA1C, glycated serum proteins and albumin, and fructosamine with the 24-h glucose profile of insulin-dependent pregnant diabetics

L Suhonen, UH Stenman, V Koivisto and K Teramo
Department of Gynecology & Obstetrics, University Central Hospital, Helsinki, Finland.

To assess the value of various methods for long-term follow-up of diabetic patients, we compared the concentrations of fructosamine in serum with those of various glycated proteins: hemoglobin (HbA1C), total serum proteins (G-prot), and albumin (G-alb), assayed in 30 pregnant insulin-dependent diabetics every two weeks after initial determination of a 24-h blood glucose profile. HbA1C correlated best with the 24-h glucose profile during the succeeding 10-35 days (r = 0.65-0.68, P less than 0.001). G-prot and G-alb correlated nearly as well as HbA1C 10-20 days after the glucose profile (r = 0.54-0.64, P less than 0.01-0.001), but only weakly after 25-35 days. Values for fructosamine did not correlate significantly with the glucose profile 10-35 days after it (r = 0.23-0.36). Evidently the fructosamine assay is not an adequate alternative to HbA1C, G-alb, or G-prot as an index to long-term control of blood glucose in such patients.


The following articles in journals at HighWire Press have cited this article:


Home page
 Diabetes CareHome page
D. E. Goldstein, R. R. Little, R. A. Lorenz, J. I. Malone, D. Nathan, C. M. Peterson, and D. B. Sacks
Tests of Glycemia in Diabetes
Diabetes Care, July 1, 2004; 27(7): 1761 - 1773.
[Full Text] [PDF]

Home page
 QJMHome page
K. Wiener and N.B. Roberts
Age does not influence levels of HbA1c in normal subject
QJM, March 1, 1999; 92(3): 169 - 173.
[Abstract] [Full Text] [PDF]


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