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Clinical Chemistry 35: 963-966, 1989;
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Clinical Chemistry, Vol 35, 963-966, Copyright © 1989 by American Association for Clinical Chemistry

Influence of end-stage renal failure on concentrations of free apolipoprotein A-1 in serum

F Duval, K Frommherz, V Atger, T Drueke and B Lacour
INSERM U 90, Hopital, Necker, Paris, France.

We determined, immunoturbidimetrically, the concentrations of apolipoprotein A-I (apo A-I) (a) in total serum, (b) in total lipoproteins, and (c) in the fraction of d greater than 1.21 kg/L (free apo A-I) in 31 uremic patients (16 on hemodialysis, HD, and 15 with end- stage renal failure, ESRF) and 14 control subjects. The concentration of free apo A-I in serum was significantly increased in both groups of uremic patients (0.27 +/- 0.07 g/L for HD and 0.22 +/- 0.08 g/L for ESRF, mean +/- SD), in comparison with the control group (0.14 +/- 0.04 g/L). The ratio of total apo A-I to high-density-lipoprotein cholesterol was significantly increased in sera from both uremic groups, whereas the apo A-I/HDL-chol ratio of total lipoproteins was similar in all three groups. No apo A-I could be detected in five ultrafiltrates of plasma, even after 100-fold concentration. Analysis of apo A-I isoforms by isoelectrofocusing revealed a significant relative increase in apo A-I3 and a decrease in apo A-I5 isoform in ESRF patients, but not in HD patients. Finally, we found no relationship between serum TG and free apo A-I concentration.


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T. Miida, O. Miyazaki, O. Hanyu, Y. Nakamura, S. Hirayama, I. Narita, F. Gejyo, I. Ei, K. Tasaki, Y. Kohda, et al.
LCAT-Dependent Conversion of Pre{beta}1-HDL into {alpha}-Migrating HDL is Severely Delayed in Hemodialysis Patients
J. Am. Soc. Nephrol., March 1, 2003; 14(3): 732 - 738.
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M. N. Nanjee and E. A. Brinton
Very Small Apolipoprotein A-I-containing Particles from Human Plasma: Isolation and Quantification by High-Performance Size-Exclusion Chromatography
Clin. Chem., February 1, 2000; 46(2): 207 - 223.
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Copyright © 1989 by the American Association for Clinical Chemistry.