Clinical Chemistry
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Clinical Chemistry 35: 1309-1312, 1989;
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Clinical Chemistry, Vol 35, 1309-1312, Copyright © 1989 by American Association for Clinical Chemistry

The continuing need for quality assessment of cyclosporine measurement

A Johnston, JT Marsden and DW Holt
Clinical Pharmacology, St Bartholomew's Hospital, London, U.K.

The returns from the United Kingdom Cyclosporin Quality Assessment Scheme were analyzed for the period June 1987 to August 1988. During this time the number of laboratories in the Scheme increased from 102 to 124 and the proportion of laboratories using nonspecific assay methods declined, as did the proportion of them measuring cyclosporine in plasma. Seven different methods were used to measure the drug in blood, and the seven methods gave seven different results when used to measure patients' samples. The results, from lowest to highest, differed by a factor of approximately 3.4. The within-assay coefficient of variation (CV) was acceptable for all methods, but the between-assay and between-center CVs were poor. HPLC gave higher CVs than did the immunoassays.


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 Journal of Pharmacy PracticeHome page
H. G. McCoy and K. R. Labrosse
State of the Art: Measurement of Drug Concentrations for Therapeutic Drug Monitoring
Journal of Pharmacy Practice, January 1, 1989; 2(6): 335 - 346.
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Copyright © 1989 by the American Association for Clinical Chemistry.