Clinical Chemistry
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Clinical Chemistry 35: 1416-1422, 1989;
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Clinical Chemistry, Vol 35, 1416-1422, Copyright © 1989 by American Association for Clinical Chemistry

The between-run component of variation in internal quality control

K Linnet
Department of Clinical Chemistry, University Hospital, Copenhagen, Denmark.

Design of control charts for the mean, the within-run component of variance, and the ratio of between-run to within-run components of variance is outlined. The between-run component of variation is the main source of imprecision for analytes determined by an enzymo- or radioimmunoassay principle; accordingly, explicit control of this component is especially relevant for these types of analytes. Power curves for typical situations are presented. I also show that a between- run component of variation puts an upper limit on the achievable power towards systematic errors. Therefore, when the between-run component of variation exceeds the within-run component, use of no more than about four controls per run is reasonable at a given concentration.


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 Journal of Pharmacy PracticeHome page
H. G. McCoy and K. R. Labrosse
State of the Art: Measurement of Drug Concentrations for Therapeutic Drug Monitoring
Journal of Pharmacy Practice, January 1, 1989; 2(6): 335 - 346.
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Copyright © 1989 by the American Association for Clinical Chemistry.