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Clinical Chemistry 35: 1663-1668, 1989;
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Clinical Chemistry, Vol 35, 1663-1668, Copyright © 1989 by American Association for Clinical Chemistry

Implications of probability analysis for interpreting results of leukocyte esterase and nitrite test strips

BJ Bolann, S Sandberg and A Digranes
Laboratory of Clinical Biochemistry, Gade Institute, University of Bergen, Haukeland Hospital, Norway.

We examined 288 urine samples, using test strips, sediment microscopy, and culture. The ability of the leukocyte esterase and nitrite test strips to detect or exclude urinary tract infection, as defined by a positive culture, was evaluated by probability analysis. We found that the diagnostic efficiency of the esterase-nitrite combination was similar to that of sediment microscopy. Moreover, once the strip test results had been obtained, little additional information was given by microscopy. The importance of estimating the prevalence, or pre-test probability, of infection before the test result is evaluated is emphasized. We conclude that, for detecting or excluding urinary-tract infection, microscopy can be replaced by the esterase and nitrite test strips. If the probability of infection predicted by the test strips is not high (or low) enough compared with medical decision limits, the samples should be cultured.


The following articles in journals at HighWire Press have cited this article:


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 Clin. Chem.Home page
M. R. Langlois, J. R. Delanghe, S. R. Steyaert, K. C. Everaert, and M. L. De Buyzere
Automated Flow Cytometry Compared with an Automated Dipstick Reader for Urinalysis
Clin. Chem., January 1, 1999; 45(1): 118 - 122.
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Copyright © 1989 by the American Association for Clinical Chemistry.