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Clinical Chemistry 35: 1746-1749, 1989;
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Clinical Chemistry, Vol 35, 1746-1749, Copyright © 1989 by American Association for Clinical Chemistry

Neopterin as a predictive marker for disease progression in human immunodeficiency virus type 1 infection

D Fuchs, TJ Spira, A Hausen, G Reibnegger, ER Werner, GW Felmayer and H Wachter
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.

We assessed the value of urinary neopterin concentrations for prognosis of disease progression in HIV-1-infected patients. Sixty-eight anti-HIV- 1 seropositive homosexuals with lymphadenopathy syndrome were tested for urinary neopterin and T-cell subset counts in 1982-83, and the incidence rate at which they developed acquired immunodeficiency syndrome (AIDS) between then and May 1988 was evaluated. Overall, 21 of 68 (30.9%) cases progressed to AIDS, with a yearly progression rate of 4-9%. The predictive value of urinary neopterin concentrations was higher (P = 0.0042) than that of CD4+ T-cell counts (P = 0.015) or the CD4+/CD8+ T-cell ratio (P = 0.022). Counts of CD8+ T-cells failed to show predictive significance (P = 0.29). Similarly, multivariate- regression analysis indicated that neopterin concentrations and CD4+ T- cell numbers were significant copredictors. Produced by human macrophages activated by interferon gamma, neopterin is thus a marker of macrophage activation via T cells. We conclude that these data demonstrate a correlation between the amount of T-cell-macrophage activation, as measured by urinary neopterin concentrations, and the progression of the disease.


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T. B. Grammer, D. Fuchs, B. O. Boehm, B. R. Winkelmann, and W. Maerz
Neopterin as a Predictor of Total and Cardiovascular Mortality in Individuals Undergoing Angiography in the Ludwigshafen Risk and Cardiovascular Health Study
Clin. Chem., June 1, 2009; 55(6): 1135 - 1146.
[Abstract] [Full Text] [PDF]


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Copyright © 1989 by the American Association for Clinical Chemistry.