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Clinical Chemistry 35: 1869-1873, 1989;
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Clinical Chemistry, Vol 35, 1869-1873, Copyright © 1989 by American Association for Clinical Chemistry

Patient-side immunoassay system with a single-use cartridge for measuring analytes in blood

I Gibbons, M Gorin, Z Yassinzadeh, P Peterson, D Besemer, K Dillon, T Burd, R Hillman, G Smoluk and M Cobb
Biotrack, Mountain View, CA 94043.

We describe an immunoassay system suited to patient-side assay of therapeutic drugs and blood proteins. The system consists of an electronic monitor and single-use plastic cartridges containing dry reagents and liquid diluents. The monitor is turned on by insertion of a cartridge. To run the test, the user applies an unmeasured drop of blood to the cartridge when prompted by the monitor. All subsequent steps are performed without further user intervention and results are provided in less than 3 min. The system hemolyzes and precisely dilutes the blood. Hemoglobin concentration is measured, then the diluted blood is precisely diluted further and mixed with two dry reagents. The drug concentration is measured by a turbidimetric latex agglutination inhibition reaction. Theophylline and hemoglobin assay results for clinical samples correlate well with results of widely used comparison methods.




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Copyright © 1989 by the American Association for Clinical Chemistry.