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Clinical Chemistry, Vol 35, 1882-1887, Copyright © 1989 by American Association for Clinical Chemistry
RL Kennedy, H Griffiths and TA Gray
Department of Medicine, Northern General Hospital, Sheffield, U.K.
An antiarrhythmic drug, amiodarone, contains 37% iodine by weight and is structurally similar to the thyroid hormones. The drug inhibits hepatic 5'-deiodinase, resulting in increases in serum thyroxin and "reverse" triiodothyronine, whereas the concentration of triiodothyronine in serum is decreased. There is a significant incidence of either hypothyroidism or hyperthyroidism in patients who are being treated with the drug. This is largely the effect of iodine released from the drug during chronic therapy, but in susceptible individuals amiodarone may unmask autoimmune thyroid disease. Some effects of the drug suggest that it may interfere with the action of thyroid hormones at the cellular level, inducing a state of localized hypothyroidism.
The following articles in journals at HighWire Press have cited this article:
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  S. Tedelind, F. Larsson, C. Johanson, H. C. van Beeren, W. M. Wiersinga, E. Nystrom, and M. Nilsson Amiodarone Inhibits Thyroidal Iodide Transport in Vitro by a Cyclic Adenosine 5'-Monophosphate- and Iodine-Independent Mechanism Endocrinology, June 1, 2006; 147(6): 2936 - 2943. [Abstract] [Full Text] [PDF]
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 S. Demolombe, C. Marionneau, S. Le Bouter, F. Charpentier, and D. Escande Functional genomics of cardiac ion channel genes Cardiovasc Res, August 15, 2005; 67(3): 438 - 447. [Abstract] [Full Text] [PDF]
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 S. Le Bouter, A. El Harchi, C. Marionneau, C. Bellocq, A. Chambellan, T. van Veen, C. Boixel, B. Gavillet, H. Abriel, K. Le Quang, et al. Long-Term Amiodarone Administration Remodels Expression of Ion Channel Transcripts in the Mouse Heart Circulation, November 9, 2004; 110(19): 3028 - 3035. [Abstract] [Full Text] [PDF]
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K. Kamiya, A. Nishiyama, K. Yasui, M. Hojo, M. C. Sanguinetti, and I. Kodama Short- and Long-Term Effects of Amiodarone on the Two Components of Cardiac Delayed Rectifier K+ Current Circulation, March 6, 2001; 103(9): 1317 - 1324. [Abstract] [Full Text] [PDF]
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 G. H. Daniels Amiodarone-Induced Thyrotoxicosis J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 3 - 8. [Full Text]
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J. Merot, F. Charpentier, J.-M. Poirier, G. Coutris, and J. Weissenburger Effects of chronic treatment by amiodarone on transmural heterogeneity of canine ventricular repolarization in vivo: interactions with acute sotalol Cardiovasc Res, November 1, 1999; 44(2): 303 - 314. [Abstract] [Full Text] [PDF]
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I. Kodama, K. Kamiya, and J. Toyama Cellular electropharmacology of amiodarone Cardiovasc Res, July 1, 1997; 35(1): 13 - 29. [Full Text] [PDF]
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G. Iervasi, A. Clerico, R. Bonini, C. Manfredi, S. Berti, M. Ravani, C. Palmieri, A. Carpi, A. Biagini, and I. J. Chopra Acute Effects of Amiodarone Administration on Thyroid Function in Patients with Cardiac Arrhythmia J. Clin. Endocrinol. Metab., January 1, 1997; 82(1): 275 - 280. [Abstract] [Full Text] [PDF]
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 Grand Rounds--St Bartholomew's Hospital: A lump in the chest BMJ, December 2, 1995; 311(7018): 1491 - 1494. [Full Text]
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