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Clinical Chemistry 35: 2009-2015, 1989;
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Clinical Chemistry, Vol 35, 2009-2015, Copyright © 1989 by the American Association for Clinical Chemistry

Standardization of the Immunochemical Determination of Apolipoproteins A-I and B: A Report on the International Federation of Clinical Chemistry Meeting on Standardization of Apolipoprotein A-I and B Measurements (Basis for Future Consensus), Vienna, Austria, April 18-19, 1989

Santica M. Marcovina 1 and John J. Albers 2

1 Laboratories of Immunochemistry and Lipoproteins, Scientific Institute San Raffaele, Milano, Italy
2 Deparments of Medicine and Pathology, University of Washington School of Medicine and Northwest Lipid Research Center, Harborview Medical Center, Seattle, WA

S. M. Marcovina, NWLRC, ZA-36, Harborview Medical Center, 326 Ninth Avenue, Seattle, WA 98104-2499

The central aim of standardization is to have accurate, reproducible apo A-I and B measurements for use in defining a person's risk for cardiovascular disease or in evaluating a therapeutic response. A common accuracy-based standardization program is indispensable in establishing international reference intervals for clinical use. It is therefore important that the standardization be implemented as soon as possible. Many problems of the standardization of apo A-I and B measurements have been presented and discussed in this meeting. Although immediate solutions to all the problems were not evident, following the recommendations from this meeting can significantly improve the standardization process.

The next step is to determine uniform reference intervals, followed by a consensus conference on apolipoproteins to define the cutpoints (cutoff values) for clinical decisions.

Submitted on June 14, 1989
Accepted on June 14, 1989




The following articles in journals at HighWire Press have cited this article:


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I. D. Cruzado, S. L. Cockrill, C. J. McNeal, and R. D. Macfarlane
Characterization and quantitation of apolipoprotein B-100 by capillary electrophoresis
J. Lipid Res., January 1, 1998; 39(1): 205 - 217.
[Abstract] [Full Text]


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