Clinical Chemistry
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Clinical Chemistry 36: 125-128, 1990;
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Clinical Chemistry, Vol 36, 125-128, Copyright © 1990 by American Association for Clinical Chemistry

Revision of the oral glucose tolerance test: a pilot study

JG Schwartz, WT Phillips and B Aghebat-Khairy
Department of Pathology, University of Texas Health Science Center, San Antonio 78284.

Nausea and vomiting have been recurrent problems with the oral glucose tolerance tests (OGTT) used to diagnose diabetes. We believe the nausea is associated with delayed gastric emptying caused by the high osmolarity of the glucose solution. In our pilot study, both the "standard" 100-g glucose OGTT and our new modified (lower osmolar) glucose solution were evaluated. Considerably delayed gastric emptying (along with severe nausea) was consistently noted with the standard OGTT. No nausea and a much more rapid gastric emptying time were recorded when the modified glucose solution was administered. We were able to diagnose diabetes (by using Wilkerson's point system) when our modified OGTT was administered to type 2 diabetics. We plan to develop a more physiological, more reproducible, and better tolerated OGTT to diagnose diabetes more accurately in the general population.




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Copyright © 1990 by the American Association for Clinical Chemistry.