Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 36: 15-19, 1990;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Warnick, G. R.
Right arrow Articles by Branson, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Warnick, G. R.
Right arrow Articles by Branson, L.

Clinical Chemistry, Vol 36, 15-19, Copyright © 1990 by American Association for Clinical Chemistry

Estimating low-density lipoprotein cholesterol by the Friedewald equation is adequate for classifying patients on the basis of nationally recommended cutpoints

GR Warnick, RH Knopp, V Fitzpatrick and L Branson
Division of Metabolism, Endocrinology and Nutrition, University of Washington, Harborview Medical Center, Seattle 98104.

We compared low-density lipoprotein cholesterol (LDL) values obtained by the Friedewald formula--i.e., total cholesterol minus high-density lipoprotein (HDL) cholesterol minus very-low-density lipoprotein (VLDL) cholesterol (estimated as triglyceride divided by 5)--with those obtained by lipoprotein fractionation, using 4736 specimens. When triglycerides were less than 2.0 g/L, greater than 90% of estimated LDL cholesterol values were acceptable, within +/- 10% of measured values. At triglyceride concentrations of 2.0-4.0 g/L and 4.0-6.0 g/L, only 72% and 39%, respectively, of the estimates were acceptable. LDL values derived from an alternative formula, estimating VLDL as triglycerides divided by 6, were even less accurate. Nevertheless, the use of estimated LDL for risk classification based on the National Cholesterol Education Program Adult Treatment Panel cutpoints of 1.30 and 1.60 g/L was considered acceptable. At triglyceride concentrations less than or equal to 5.0 g/L, 88% of classifications based on estimated LDL (using triglycerides divided by 5) were concordant with those by measured LDL. Eleven percent of classifications were shifted across one cutpoint, evenly distributed between high and low. Fewer than 1% of classifications, all with Type III hyperlipoproteinemia, were misclassified two cutpoints high. Refinements in the estimation model did not substantially improve LDL estimation or concordance of risk classification.


The following articles in journals at HighWire Press have cited this article:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T.-M. Lee, M.-S. Lin, C.-H. Tsai, C.-L. Huang, and N.-C. Chang
Effects of sulfonylureas on left ventricular mass in type 2 diabetic patients
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H608 - H613.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. R. Abdollahi, P. A.I. Guthrie, G. D. Smith, D. A. Lawlor, S. Ebrahim, and I. N.M. Day
Integrated Single-Label Liquid-Phase Assay of APOE Codons 112 and 158 and a Lipoprotein Study in British Women,
Clin. Chem., July 1, 2006; 52(7): 1420 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
R. Jago, J. S. Harrell, R. G. McMurray, S. Edelstein, L. El Ghormli, and S. Bassin
Prevalence of abnormal lipid and blood pressure values among an ethnically diverse population of eighth-grade adolescents and screening implications.
Pediatrics, June 1, 2006; 117(6): 2065 - 2073.
[Abstract] [Full Text] [PDF]

Home page
 J CARDIOVASC PHARMACOL THERHome page
E. T. Bairaktari, K. I. Seferiadis, and M. S. Elisaf
Evaluation of Methods for the Measurement of Low-Density Lipoprotein Cholesterol
Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 2005; 10(1): 45 - 54.
[Abstract] [PDF]

Home page
 Clin. Chem.Home page
R. Rej
Clinical Chemistry through Clinical Chemistry: A Journal Timeline
Clin. Chem., December 1, 2004; 50(12): 2415 - 2458.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
A. Wiegman, B. A. Hutten, E. de Groot, J. Rodenburg, H. D. Bakker, H. R. Buller, E. J. G. Sijbrands, and J. J. P. Kastelein
Efficacy and Safety of Statin Therapy in Children With Familial Hypercholesterolemia: A Randomized Controlled Trial
JAMA, July 21, 2004; 292(3): 331 - 337.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. J. Hukshorn, J. H. N. Lindeman, K. H. Toet, W. H. M. Saris, P. H. C. Eilers, M. S. Westerterp-Plantenga, and T. Kooistra
Leptin and the Proinflammatory State Associated with Human Obesity
J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1773 - 1778.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
L. Sun, Z. Li, H. Zhang, A. Ma, Y. Liao, D. Wang, B. Zhao, Z. Zhu, J. Zhao, Z. Zhang, et al.
Pentanucleotide TTTTA Repeat Polymorphism of Apolipoprotein(a) Gene and Plasma Lipoprotein(a) Are Associated With Ischemic and Hemorrhagic Stroke in Chinese: A Multicenter Case-Control Study in China
Stroke, July 1, 2003; 34(7): 1617 - 1622.
[Abstract] [Full Text] [PDF]

Home page
 J. Epidemiol. Community HealthHome page
D A Lawlor, C Bedford, M Taylor, and S Ebrahim
Geographical variation in cardiovascular disease, risk factors, and their control in older women: British Women's Heart and Health Study
J. Epidemiol. Community Health, February 1, 2003; 57(2): 134 - 140.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Nauck, G. R. Warnick, and N. Rifai
Methods for Measurement of LDL-Cholesterol: A Critical Assessment of Direct Measurement by Homogeneous Assays versus Calculation
Clin. Chem., February 1, 2002; 48(2): 236 - 254.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
H. Fei, S. Maeda, H. Kirii, S. Fujigaki, N. Maekawa, H. Fujii, H. Wada, K. Saito, and M. Seishima
Evaluation of Two Different Homogeneous Assays for LDL-Cholesterol in Lipoprotein-X-positive Serum
Clin. Chem., September 1, 2000; 46(9): 1351 - 1356.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Esteban-Salan, A. Guimon-Bardesi, J. M. de la Viuda-Unzueta, M. N. Azcarate-Ania, P. Pascual-Usandizaga, and E. Amoroto-Del-Rio
Analytical and Clinical Evaluation of Two Homogeneous Assays for LDL-Cholesterol in Hyperlipidemic Patients
Clin. Chem., August 1, 2000; 46(8): 1121 - 1131.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
H. Sugiuchi, T. Irie, Y. Uji, T. Ueno, T. Chaen, K. Uekama, and H. Okabe
Homogeneous assay for measuring low-density lipoprotein cholesterol in serum with triblock copolymer and {alpha}-cyclodextrin sulfate
Clin. Chem., March 1, 1998; 44(3): 522 - 531.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. Johnson, P. McNutt, S. MacMahon, and R. Robson
Use of the Friedewald Formula to Estimate LDL-Cholesterol in Patients with Chronic Renal Failure on Dialysis
Clin. Chem., November 1, 1997; 43(11): 2183 - 2184.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Maitra, S. V. Hirany, and I. Jialal
Comparison of two assays for measuring LDL cholesterol
Clin. Chem., June 1, 1997; 43(6): 1040 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
T. Planella, M. Cortes, C. Martinez-Bru, F. Gonzalez-Sastre, and J. Ordonez-Llanos
Calculation of LDL-cholesterol by using apolipoprotein B for classification of nonchylomicronemic dyslipemia
Clin. Chem., May 1, 1997; 43(5): 808 - 815.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by the American Association for Clinical Chemistry.