| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Chemistry, Vol 36, 20-23, Copyright © 1990 by American Association for Clinical Chemistry
M Sandkamp, H Funke, H Schulte, E Kohler and G Assmann
Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitatskliniken der Westfalischen Wilhelms-Universitat Munster, F.R.G.
We quantified lipoprotein(a) [Lp(a)] immunochemically in young (less than 46 y) male survivors of myocardial infarction and in age-matched controls recruited from participants of the Prospective Cardiovascular Munster (PROCAM) study. We further determined apolipoprotein E polymorphism and measured triglycerides, total cholesterol, high- and low-density lipoprotein cholesterol (HDL and LDL), and apolipoproteins AI, AII, and B in the serum of these subjects. Lp(a) concentrations in serum were not correlated with other well-recognized risk factors for early myocardial infarction such as apolipoproteins AI and B, LDL cholesterol, and HDL cholesterol. Apolipoprotein E polymorphism did not affect Lp(a) concentrations, but had a major influence on apolipoprotein B concentration. Lp(a) concentrations were not influenced by age. Our data suggest that (a) an increased concentration of Lp(a) constitutes an independent risk factor for early myocardial infarction and (b) the concentrations of Lp(a) and LDL cholesterol (apolipoprotein B) in serum are under separate metabolic control.
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  S. Kiechl, J. Willeit, M. Mayr, B. Viehweider, M. Oberhollenzer, F. Kronenberg, C. J. Wiedermann, S. Oberthaler, Q. Xu, J. L. Witztum, et al. Oxidized Phospholipids, Lipoprotein(a), Lipoprotein-Associated Phospholipase A2 Activity, and 10-Year Cardiovascular Outcomes: Prospective Results From the Bruneck Study Arterioscler Thromb Vasc Biol, August 1, 2007; 27(8): 1788 - 1795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Anuurad, G. Lu, J. Rubin, T. A. Pearson, and L. Berglund ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Study J. Lipid Res., March 1, 2007; 48(3): 693 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tsimikas, J. T. Willerson, and P. M. Ridker C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J. Am. Coll. Cardiol., April 18, 2006; 47(8 Suppl): C19 - C31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tsimikas, E. S. Brilakis, E. R. Miller, J. P. McConnell, R. J. Lennon, K. S. Kornman, J. L. Witztum, and P. B. Berger Oxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease N. Engl. J. Med., July 7, 2005; 353(1): 46 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Assmann Calculating global risk: the key to intervention Eur. Heart J. Suppl., July 1, 2005; 7(suppl_F): F9 - F14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. T. Bairaktari, K. I. Seferiadis, and M. S. Elisaf Evaluation of Methods for the Measurement of Low-Density Lipoprotein Cholesterol Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 2005; 10(1): 45 - 54. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Rej Clinical Chemistry through Clinical Chemistry: A Journal Timeline Clin. Chem., December 1, 2004; 50(12): 2415 - 2458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tholstrup and S. Samman Postprandial Lipoprotein(a) Is Affected Differently by Specific Individual Dietary Fatty Acids in Healthy Young Men J. Nutr., October 1, 2004; 134(10): 2550 - 2555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. WAHN, V. DANIEL, F. KRONENBERG, G. OPELZ, D. V. MICHALK, and U. QUERFELD Impact of Apolipoprotein(a) Phenotypes on Long-Term Renal Transplant Survival J. Am. Soc. Nephrol., May 1, 2001; 12(5): 1052 - 1058. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Stenvinkel, B. Lindholm, M. Heimburger, and O. Heimburger Elevated serum levels of soluble adhesion molecules predict death in pre-dialysis patients: association with malnutrition, inflammation, and cardiovascular disease Nephrol. Dial. Transplant., October 1, 2000; 15(10): 1624 - 1630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Harjai Potential New Cardiovascular Risk Factors: Left Ventricular Hypertrophy, Homocysteine, Lipoprotein(a), Triglycerides, Oxidative Stress, and Fibrinogen Ann Intern Med, September 7, 1999; 131(5): 376 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. T. Raitakari, M. R. Adams, and D. S. Celermajer Effect of Lp(a) on the Early Functional and Structural Changes of Atherosclerosis Arterioscler Thromb Vasc Biol, April 1, 1999; 19(4): 990 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Querfeld, S. Döpper, A. Gradehand, P. Kiencke, F. Wahn, and H.-J. Zeisel Long-Term Treatment with Growth Hormone Has No Persisting Effect on Lipoprotein(a) in Patients with Turner's Syndrome J. Clin. Endocrinol. Metab., March 1, 1999; 84(3): 967 - 970. [Abstract] [Full Text]
|
|
|
|
|
|
E. Anglés-Cano, S. Loyau, G. Cardoso-Saldaña, R. Couderc, and P. Gillery A novel kringle-4 number-based recombinant apo[a] standard for human apo[a] phenotyping J. Lipid Res., February 1, 1999; 40(2): 354 - 359. [Abstract] [Full Text]
|
|
|
|
|
|
C. Gazzaruso, A. Garzaniti, P. Buscaglia, G. Bonetti, C. Falcone, P. Fratino, G. Finardi, and D. Geroldi Association between apolipoprotein(a) phenotypes and coronary heart disease at a young age J. Am. Coll. Cardiol., January 1, 1999; 33(1): 157 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Islam, B. Gutin, F. Treiber, G. Hobbs, I. Kamboh, and M. Lopes-Virella Association of Apolipoprotein A Phenotypes and Oxidized Low-Density Lipoprotein Immune Complexes in Children Arch Pediatr Adolesc Med, January 1, 1999; 153(1): 57 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gaw, E. A. Brown, and I. Ford Impact of Apo(a) Length Polymorphism and the Control of Plasma Lp(a) Concentrations : Evidence for a Threshold Effect Arterioscler Thromb Vasc Biol, December 1, 1998; 18(12): 1870 - 1876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Morishita, S. Yamada, J. Higaki, N. Tomita, I. Kida, M. Aoki, A. Moriguchi, S.-i. Hayashi, I. Sakurabayashi, Y. Kaneda, et al. Conditioned Medium From HepG2 Cells Transfected With Human Apolipoprotein(a) Gene Stimulates Growth of Human Vascular Smooth Muscle Cells : Effects of Overexpression of Human Apolipoprotein(a) Gene Hypertension, August 1, 1998; 32(2): 215 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. McNamara, P. K. Shah, K. Nakajima, L. A. Cupples, P. W. F. Wilson, J. M. Ordovas, and E. J. Schaefer Remnant lipoprotein cholesterol and triglyceride reference ranges from the Framingham Heart Study Clin. Chem., June 1, 1998; 44(6): 1224 - 1232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. N. Hopkins, L. L. Wu, S. C. Hunt, B. C. James, G. M. Vincent, and R. R. Williams Lipoprotein(a) Interactions With Lipid and Nonlipid Risk Factors in Early Familial Coronary Artery Disease Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2783 - 2792. [Abstract] [Full Text]
|
|
|
|
|
|
W.-K. Min, J. O. Lee, and J. W. Huh Relation between lipoprotein(a) concentrations in patients with acute-phase response and risk analysis for coronary heart disease Clin. Chem., October 1, 1997; 43(10): 1891 - 1895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Stein and R. S. Rosenson Lipoprotein Lp(a) Excess and Coronary Heart Disease Arch Intern Med, June 9, 1997; 157(11): 1170 - 1176. [Abstract] [PDF]
|
|
|
|
 |
|
 U. Nowak-Gottl, O. Debus, M. Findeisen, R. Kassenbohmer, H. G. Koch, H. Pollmann, C. Postler, P. Weber, and H. Vielhaber Lipoprotein (a): Its Role in Childhood Thromboembolism Pediatrics, June 1, 1997; 99(6): e11 - e11. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Catalano, E. Perilli, G. Carzaniga, G. Scandale, and M. Carotta Arterial Damage, Triglycerides, Apolipoprotein, and Lp-(a) Values in PVD Patients Clinical and Applied Thrombosis/Hemostasis, April 1, 1997; 3(2): 104 - 109. [Abstract] [PDF]
|
|
|
|
 |
|
 F. van Kooten, J. van Krimpen, D. W.J. Dippel, N. Hoogerbrugge, and P. J. Koudstaal Lipoprotein(a) in Patients With Acute Cerebral Ischemia Stroke, July 1, 1996; 27(7): 1231 - 1235. [Abstract] [Full Text]
|
|
|
|
|
|
M. Margaglione, G. DiMinno, E. Grandone, E. Celentano, G. Vecchione, G. Cappucci, M. Grilli, F. P. Mancini, A. Postiglione, S. Panico, et al. Plasma Lipoprotein(a) Levels in Subjects Attending a Metabolic Ward : Discrimination Between Individuals With and Without a History of IschemicStroke Arterioscler Thromb Vasc Biol, January 1, 1996; 16(1): 120 - 128. [Abstract] [Full Text]
|
|
|
|
 |
|
 V. M. G. Maher, B. G. Brown, S. M. Marcovina, L. A. Hillger, X.-Q. Zhao, and J. J. Albers Effects of Lowering Elevated LDL Cholesterol on the Cardiovascular Risk of Lipoprotein(a) JAMA, December 13, 1995; 274(22): 1771 - 1774. [Abstract] [PDF]
|
|
|
|
|
|
I. Bolibar, S. G. Thompson, A. von Eckardstein, M. Sandkamp, and G. Assmann Dose-Response Relationships of Serum Lipid Measurements With the Extent of Coronary Stenosis : Strong, Independent, and Comprehensive Arterioscler Thromb Vasc Biol, August 1, 1995; 15(8): 1035 - 1042. [Abstract] [Full Text]
|
|
|
|
|
|
P. M. Ridker, M. J. Stampfer, and C. H. Hennekens Plasma Concentration of Lipoprotein(a) and the Risk of Future Stroke JAMA, April 26, 1995; 273(16): 1269 - 1273. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Haber Angiotensin-Converting Enzyme and Lipoprotein(a) as Risk Factors for Myocardial Infarction Circulation, March 15, 1995; 91(6): 1888 - 1890. [Full Text]
|
|
|
|
|
|
R. J. Valentine, P. A. Grayburn, G. L. Vega, and S. M. Grundy Lp(a) Lipoprotein Is an Independent, Discriminating Risk Factor for Premature Peripheral Atherosclerosis Among White Men Arch Intern Med, April 11, 1994; 154(7): 801 - 806. [Abstract] [PDF]
|
|
|
|
|
|
E. J. Schaefer, S. Lamon-Fava, J. L. Jenner, J. R. McNamara, J. M. Ordovas, C. E. Davis, J. M. Abolafia, K. Lippel, and R. I. Levy Lipoprotein(a) Levels and Risk of Coronary Heart Disease in Men: The Lipid Research Clinics Coronary Primary Prevention Trial JAMA, April 6, 1994; 271(13): 999 - 1003. [Abstract] [PDF]
|
|
|
|
|
|
P. M. Ridker, C. H. Hennekens, and M. J. Stampfer A Prospective Study of Lipoprotein(a) and the Risk of Myocardial Infarction JAMA, November 10, 1993; 270(18): 2195 - 2199. [Abstract] [PDF]
|
|
|
|
|
|
E. S. Barnathan Has Lipoprotein 'Little' (a) Shrunk? JAMA, November 10, 1993; 270(18): 2224 - 2225. [Abstract] [PDF]
|
|
|
|
 |
|
 R. J. Valentine Lipoprotein(a): A New Risk Factor for Vascular Disease Perspectives in Vascular Surgery and Endovascular Therapy, January 1, 1992; 5(2): 84 - 99. [PDF]
|
|
|
|
 |
|
 X. Nogues, M. Seni, J. Pedro-Botet, J. Rubies-Prat, and F. Vidal-Barraquer Serum Lipoprotein (a) Levels in Men with Peripheral Vascular Disease Angiology, August 1, 1991; 42(8): 659 - 664. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
