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Clinical Chemistry 36: 1765-1768, 1990;
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Clinical Chemistry, Vol 36, 1765-1768, Copyright © 1990 by American Association for Clinical Chemistry

Improved methods for genotype determination of human alcohol dehydrogenase (ADH) at ADH 2 and ADH 3 loci by using polymerase chain reaction-directed mutagenesis

A Groppi, J Begueret and A Iron
Laboratoire de Genetique, CNRS UA 542, Talence, France.

The human gene for producing alcohol dehydrogenase (ADH; EC 1.1.1.1) is polymorphic at ADH 2 and ADH 3 loci. Until now, the study of this polymorphism required liver biopsy or allele-specific radioactive probes. We have used directed mutagenesis by the polymerase chain reaction (PCR) to amplify and analyze the genotype of ADH 2 and ADH 3 loci. Thus, we could determine easily and unambiguously the complete genotype at these two loci by using a microsample of blood and restriction fragment length polymorphism after DNA amplification by PCR.


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