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Clinical Chemistry 36: 1815-1819, 1990;
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Clinical Chemistry, Vol 36, 1815-1819, Copyright © 1990 by American Association for Clinical Chemistry

Improved method for identifying alpha 1-antitrypsin Pi M subtypes by isoelectric focusing in agarose

ML Nowicki and EF Freier
Department of Laboratory Medicine and Pathology, University of Minnesota Hospital and Clinic, Minneapolis 55455.

We describe an improved method for the classification of alpha 1- antitrypsin variants by isoelectric focusing in agarose. Identification of the three Pi M subtypes can now be made by using a narrow-range carrier ampholyte (pH 4.2-4.9) and pretreating serum with dithioerythritol-iodoacetic acid to enhance band resolution. Phenotype results for two groups of Pi M homo- and heterozygotes are compared to illustrate the improved accuracy of the new method.




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