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Clinical Chemistry 36: 188-191, 1990;
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Clinical Chemistry, Vol 36, 188-191, Copyright © 1990 by American Association for Clinical Chemistry

Biochemical markers as prognostic indices in breast cancer

MJ Duffy
Nuclear Medicine Dept., St. Vincent's Hospital, Dublin 4, Ireland.

Traditional prognostic markers in breast cancer include histological variables such as tumor size, grade, and axillary node status. In recent years some new potential prognostic markers of a biochemical nature have been described: estradiol receptors, progesterone receptors, epidermal growth factor receptors, erbB-2 proto-oncogene, and certain proteolytic enzymes. None of these new markers excels axillary node status as a prognostic marker. Biochemical markers can, however, be evaluated with use of minimal surgery and may help distinguish the minority of aggressive axillary-node-negative breast cancers.


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 Clin. Chem.Home page
M. J. Duffy
Predictive Markers in Breast and Other Cancers: A Review
Clin. Chem., March 1, 2005; 51(3): 494 - 503.
[Abstract] [Full Text] [PDF]


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