Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 36: 192-197, 1990;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wong, W. L.
Right arrow Articles by Hass, P. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wong, W. L.
Right arrow Articles by Hass, P. E.

Clinical Chemistry, Vol 36, 192-197, Copyright © 1990 by American Association for Clinical Chemistry

A monoclonal-antibody-based enzyme-linked immunosorbent assay of lipoprotein(a)

WL Wong, DL Eaton, A Berloui, B Fendly and PE Hass
Department Immunology Research & Assay Technology, Genentech, Inc., San Francisco, CA 94080.

Lipoprotein(a) [Lp(a)] is a low-density lipoprotein (LDL)-like lipoprotein particle recently described as a risk factor for premature coronary heart disease, stroke, and atherosclerosis. Structurally, Lp(a) is similar to LDL in that it has comparable lipid composition and contains apolipoprotein B-100 (apo B-100). In addition, Lp(a) contains the glycoprotein apolipoprotein(a) [apo(a)], which is disulfide-linked to apo B-100. The recent awareness of a striking correlation between atherosclerosis and concentrations of Lp(a) in plasma prompted our development of an accurate quantitative assay for plasma Lp(a), a monoclonal-antibody-based enzyme-linked immunosorbent assay for Lp(a) that is shown to be sensitive, precise, and highly specific. The response to several isoforms of Lp(a) is linear, and as many as 80 samples can be quantified on one plate. This easily performed assay is suitable for use in the clinical laboratory and for screening large populations.


The following articles in journals at HighWire Press have cited this article:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. H. Klein, R. A. Hegele, D. G. Hackam, M. L. Koschinsky, M. W. Huff, and J. D. Spence
Lipoprotein(a) Is Associated Differentially With Carotid Stenosis, Occlusion, and Total Plaque Area
Arterioscler Thromb Vasc Biol, October 1, 2008; 28(10): 1851 - 1856.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. D. Sturgeon, A. R. Folsom, W.T. Longstreth Jr, E. Shahar, W. D. Rosamond, and M. Cushman
Hemostatic and Inflammatory Risk Factors for Intracerebral Hemorrhage in a Pooled Cohort
Stroke, August 1, 2008; 39(8): 2268 - 2273.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. A. Ariyo, C. Thach, R. Tracy, and the Cardiovascular Health Study Investigators
Lp(a) Lipoprotein, Vascular Disease, and Mortality in the Elderly
N. Engl. J. Med., November 27, 2003; 349(22): 2108 - 2115.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
A. W. Tsai, M. Cushman, W. D. Rosamond, S. R. Heckbert, J. F. Polak, and A. R. Folsom
Cardiovascular Risk Factors and Venous Thromboembolism Incidence: The Longitudinal Investigation of Thromboembolism Etiology
Arch Intern Med, May 27, 2002; 162(10): 1182 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
J. Xia, L. F. May, and M. L. Koschinsky
Characterization of the basis of lipoprotein [a] lysine-binding heterogeneity
J. Lipid Res., October 1, 2000; 41(10): 1578 - 1584.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. A. Sakkinen, M. Cushman, B. M. Psaty, B. Rodriguez, R. Boineau, L. H. Kuller, and R. P. Tracy
Relationship of Plasmin Generation to Cardiovascular Disease Risk Factors in Elderly Men and Women
Arterioscler Thromb Vasc Biol, March 1, 1999; 19(3): 499 - 504.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. P. Tracy, B. M. Psaty, E. Macy, E. G. Bovill, M. Cushman, E. S. Cornell, and L. H. Kuller
Lifetime Smoking Exposure Affects the Association of C-Reactive Protein with Cardiovascular Disease Risk Factors and Subclinical Disease in Healthy Elderly Subjects
Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 2167 - 2176.
[Abstract] [Full Text]

Home page
 CirculationHome page
B. J. Biemond, P. W. Friederich, M. L. Koschinsky, M. Levi, W. Sangrar, J. Xia, H. R. Buller, and J. W. t. Cate
Apolipoprotein(a) Attenuates Endogenous Fibrinolysis in the Rabbit Jugular Vein Thrombosis Model In Vivo
Circulation, September 2, 1997; 96(5): 1612 - 1615.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
B. R. Gabel, L. F. May, S. M. Marcovina, and M. L. Koschinsky
Lipoprotein(a) Assembly: Quantitative Assessment of the Role of Apo(a) Kringle IV Types 2-10 in Particle Formation
Arterioscler Thromb Vasc Biol, December 1, 1996; 16(12): 1559 - 1567.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Cushman, B. M. Psaty, E. Macy, E. G. Bovill, E. S. Cornell, L. H. Kuller, and R. P. Tracy
Correlates of Thrombin Markers in an Elderly Cohort Free of Clinical Cardiovascular Disease
Arterioscler Thromb Vasc Biol, September 1, 1996; 16(9): 1163 - 1169.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by the American Association for Clinical Chemistry.