Clinical Chemistry
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Clinical Chemistry 36: 304-306, 1990;
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Clinical Chemistry, Vol 36, 304-306, Copyright © 1990 by American Association for Clinical Chemistry

Increased activities of cytosol aminopeptidase and lactate dehydrogenase in serum originate from lymphocytes in necrotizing lymphadenitis

N Sugaya, T Kanno, M Nirasawa, K Mitamura, Y Takeuchi and M Osano
Department of Pediatrics, Nippon Kokan Hospital, Kanagawa, Japan.

In three pediatric patients with necrotizing lymphadenitis, cytosol aminopeptidase activity (c-AP; EC 3.4.11.1) in serum was markedly increased to 509, 417, and 191 U/L, respectively (normal range 25-60 U/L). Lactate dehydrogenase (LD; EC 1.1.1.27) was also increased, with LD-3 predominating. The increased concentrations of c-AP and LD presumably originated from the destruction of infected, activated lymphocytes, especially T lymphocytes. Necrotizing lymphadenitis is probably caused by a lymphocytotropic virus.




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Copyright © 1990 by the American Association for Clinical Chemistry.