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Clinical Chemistry 36: 346-348, 1990;
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Clinical Chemistry, Vol 36, 346-348, Copyright © 1990 by American Association for Clinical Chemistry

Aminotransferase as a prognostic index in infants with liver disease

P Rosenthal and M Haight
Department of Pediatrics, Childrens Hospital of Los Angeles, CA.

To assess the utility of the serum aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio in a group of infants with liver disorders, we retrospectively analyzed the charts of 73 infants with chronic liver disorders. Patients were considered as having either a good outcome (n = 40) or a poor outcome (n = 33), based upon the clinical course. AST and ALT in serum were measured simultaneously at the time of initial presentation and at various follow-up visits during the first 13 months after birth. At presentation (mean age 1.65 months), there was no difference in the AST/ALT ratios between the good (1.61 +/- 0.62; mean +/- SD) and poor (1.65 +/- 0.78) outcome groups (P = 0.81). However, over time, the AST/ALT ratio increased in patients in the poor-outcome group and decreased in patients in the good-outcome group. Calculating the AST/ALT ratio appears to be an easy, early, and reliable prognostic indicator for infants with hepatic disease, and may be a useful measure for evaluating liver-disease patients.


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P. Rosenthal
Assessing liver function and hyperbilirubinemia in the newborn
Clin. Chem., January 1, 1997; 43(1): 228 - 234.
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Copyright © 1990 by the American Association for Clinical Chemistry.