Clinical Chemistry
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Clinical Chemistry 36: 358-361, 1990;
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Clinical Chemistry, Vol 36, 358-361, Copyright © 1990 by American Association for Clinical Chemistry

Discriminant functions in differential diagnosis of hypercalcemic patients

JA Gibb, SA Ogston, CR Paterson and JR Evans
Department of Biochemical Medicine, Stracathro Hospital, Angus, Scotland, U.K.

Using readily available biochemical assays of plasma and urine constituents, we have defined discriminant functions useful as a guide to the differential diagnosis of patients with hypercalcemia. The decreasing rank order of contribution of the variables to the discriminant functions was as follows: plasma albumin, plasma phosphate, plasma chloride, log10 (calcium excretion per liter of glomerular filtrate), and log10 (plasma gamma-glutamyltransferase). Discriminant functions have been defined for patients with values for plasma creatinine above and below 185 mumol/L, and for practical conditions in which plasma and urine samples, or plasma samples only, are available.





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