Clinical Chemistry
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Clinical Chemistry 36: 395-397, 1990;
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Clinical Chemistry, Vol 36, 395-397, Copyright © 1990 by American Association for Clinical Chemistry

Valproic acid-associated pancreatitis: report of three cases and a brief review

JA Lott, LW Bond, RC Bobo, HJ McClung and RD Murray
Department of Pathology, Ohio State University, Columbus 43210.

We describe three patients with seizure disorders in whom pancreatitis or pancreatic injury was probably caused by valproic acid, a widely used anticonvulsant drug. Trivial or no increases of serum amylase (EC 3.2.1.1) but striking increases of serum lipase (EC 3.1.1.3) were common to all patients, as assayed in the Kodak Ektachem. In vitro, valproic acid does not cause any change in serum lipase. In patients with symptoms suggestive of pancreatitis and abnormal values for amylase and (or) lipase, treatment with valproic acid should be discontinued.


The following articles in journals at HighWire Press have cited this article:


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 J Child NeurolHome page
D. B. Sinclair, M. Berg, and R. Breault
Valproic Acid Induced Pancreatitis in Childhood Epilepsy: Case Series and Review
J Child Neurol, July 1, 2004; 19(7): 498 - 502.
[Abstract] [PDF]

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 CLIN PEDIATRHome page
J. D. Tobias, C. Capers, P. Sims, and G. W. Holcomb
Necrotizing Pancreatitis After 10 Years of Therapy with Valproic Acid
Clinical Pediatrics, August 1, 1995; 34(8): 446 - 448.
[PDF]


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