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Clinical Chemistry 36: 470-473, 1990;
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Clinical Chemistry, Vol 36, 470-473, Copyright © 1990 by American Association for Clinical Chemistry

Concentrations of free thyroxin and free triiodothyronine in serum of patients with thyroxin- and triiodothyronine-binding autoantibodies

R John, R Henley and D Shankland
Department of Medical Biochemistry, University Hospital of Wales, Heath Park, Cardiff, U.K.

Between 1982 and 1989 we identified 47 subjects with spuriously increased concentrations of free thyroxin (FT4) or free triiodothyronine (FT3) related to autoantibody interference in analog FT4 and (or) FT3 methods. The incidence of autoantibody interference observed during one year (1988) was 1 in 2460. In the subjects identified, 51% and 11%, respectively, showed an increased binding of radiolabeled T4 or T3 analog alone; 38% had an increased binding of both. Of 36 patients tested, 71% had autoantibodies to thyroglobulin and microsomal fraction of the thyroid, 19% to microsomal fraction alone, and 9.5% to thyroglobulin alone. In eight subjects, spuriously increased FT4 concentrations were reported with the following FT4 methods (in decreasing order of interference): Coat-A-Count, Amerlex-M, Amerlite, Seria, Magic Lite, Amerlex-MAB. In the same eight subjects, Amerlex-M and Seria reported spuriously increased concentrations of FT3.


The following articles in journals at HighWire Press have cited this article:


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G. van der Watt, D. Haarburger, and P. Berman
Euthyroid Patient with Elevated Serum Free Thyroxine
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K. Iwahara, C. Tanabe, K. Nishiyama, H. Ohashi, and M. Maekawa
Falsely High Serum Free Triiodothyronine and Free Thyroxine Concentrations Attributable to Anti-Diiodothyronine and Anti-Triiodothyronine Antibodies
Clin. Chem., June 1, 2005; 51(6): 1071 - 1072.
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J. E.M. Midgley
Direct and Indirect Free Thyroxine Assay Methods: Theory and Practice
Clin. Chem., August 1, 2001; 47(8): 1353 - 1363.
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N. Despres and A. M. Grant
Antibody interference in thyroid assays: a potential for clinical misinformation
Clin. Chem., March 1, 1998; 44(3): 440 - 454.
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