Clinical Chemistry
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Clinical Chemistry 36: 522-524, 1990;
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Clinical Chemistry, Vol 36, 522-524, Copyright © 1990 by American Association for Clinical Chemistry

Basement membrane-related and type III procollagen-related antigens in serum of patients with chronic viral liver disease

M Misaki, T Shima, Y Yano, Y Sumita, U Kano, T Murata, S Watanabe and S Suzuki
Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.

To assess the significance of serum basement membrane- and type III procollagen-related antigens in reflecting the degree of liver fibrosis, we measured radioimmunologically the concentrations of 7S collagen, laminin fragment P1, and the aminoterminal propeptide of type III procollagen (P-III-P) in serum from 48 patients with chronic viral liver disease: chronic persistent hepatitis (9), chronic active hepatitis (13), chronic active hepatitis with lobular disorganization (17), and liver cirrhosis (9). Concentrations of 7S collagen, laminin P1, and P-III-P in serum were increased in respectively 92%, 69%, and 77% of the patients with both chronic active hepatitis with lobular disorganization and liver cirrhosis. Concentrations of 7S collagen and laminin P1 in serum correlated well (r = 0.65, P less than 0.001, and r = 0.55, P less than 0.001, respectively) with the histological grade of liver fibrosis, whereas P-III-P correlated only weakly (r = 0.33, P less than 0.05). Evidently, measurement of serum 7S collagen is a reliable noninvasive test for detection of fibrosis in chronic viral liver disease.


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Copyright © 1990 by the American Association for Clinical Chemistry.