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Clinical Chemistry 36: 651-655, 1990;
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Clinical Chemistry, Vol 36, 651-655, Copyright © 1990 by American Association for Clinical Chemistry

Human choriogonadotropin (hCG): comparisons between determinations of intact hCG, free hCG beta-subunit, and "total" hCG + beta in serum during the first half of high-risk pregnancy

CM Thomas, FJ Reijnders, MF Segers, WH Doesburg and R Rolland
Department of Obstetrics and Gynaecology, Sint-Radboud Hospital, Catholic University Nijmegen, The Netherlands.

We have studied the concentrations of intact human choriogonadotropin (hCG) and the free hCG beta-subunit in blood samples from singleton pregnancies at risk for habitual or threatened abortion. The samples were obtained weekly between the 6th and 12th weeks and in the 14th and 16th weeks of gestational age. The concentrations of intact hCG, of the free hCG beta-subunit, and of "total" hCG (i.e., intact hCG and the free hCG beta-subunit: hCG + beta) were measured in serum by specific immunoassays. The distributional statistics (the 5th, 50th, and 95th percentiles) of "total" hCG + beta and of intact hCG showed very similar patterns, whereas the response curves for the free hCG beta- subunit showed very much lower serum concentrations. From these data we also estimated distributional statistics of the percent molar ratios of free hCG beta-subunit to intact hCG. We conclude that (a) the relatively small proportion of free hCG beta-subunit in serum during the first half of singleton pregnancy is far too low to interfere with the applied "total" hCG assay, as compared with the serum values obtained for intact hCG, and (b) the percent molar ratios of free hCG beta-subunit to intact hCG, or to "total" hCG + beta, never exceeded 1.0% throughout the period of pregnancy studied.


The following articles in journals at HighWire Press have cited this article:


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Z. Cao and R. Rej
Are Laboratories Reporting Serum Quantitative hCG Results Correctly?
Clin. Chem., April 1, 2008; 54(4): 761 - 764.
[Abstract] [Full Text] [PDF]

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 Eur J EndocrinolHome page
N. E van Trommel, F. C G J Sweep, C. P T Schijf, L. F A G Massuger, and C. M G Thomas
Diagnosis of hydatidiform mole and persistent trophoblastic disease: diagnostic accuracy of total human chorionic gonadotropin (hCG), free hCG {alpha}- and {beta}-subunits, and their ratios
Eur. J. Endocrinol., October 1, 2005; 153(4): 565 - 575.
[Abstract] [Full Text] [PDF]


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