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Clinical Chemistry 36: 656-658, 1990;
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Clinical Chemistry, Vol 36, 656-658, Copyright © 1990 by American Association for Clinical Chemistry

Specificities compared for a radioreceptor assay and a radioimmunoassay of atrial natriuretic peptide

SJ Capper, SW Smith, CA Spensley and JG Whateley
Amersham International plc, Life Sciences Business, Whitchurch, Cardiff, U.K.

The main active form of atrial natriuretic peptide (ANP) in the circulation is alpha ANP(1-28) [gamma-ANP(99-126)], although some active and inactive metabolites are also though to be present. Some immunoassays for alpha ANP reportedly detect inactive metabolites, as determined by their comparison with results by receptor assay, which would lead to misleading results for alpha ANP(1-28) measurements. Here we compare a radioreceptor assay (RRA) and a radioimmunoassay (RIA) for alpha ANP and show that their results correlate very well with regard to specificity and that the RIA appears to detect only the active circulating form of alpha ANP(1-28).




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