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Clinical Chemistry 36: 674-676, 1990;
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Clinical Chemistry, Vol 36, 674-676, Copyright © 1990 by American Association for Clinical Chemistry

Use of free and transthyretin-bound retinol-binding protein in serum as tests of vitamin A status in humans: effect of high creatinine concentrations in serum

BJ Burri, DD Bankson and TR Neidlinger
Western Human Nutrition Research Center, USDA/ARS/PWA, Presidio of San Francisco, CA 94129.

We measured immunologically active (apo + holo) retinol-binding protein (RBP), vitamin A-carrying (holo) free RBP, and transthyretin-bound (TTR) holo-RBP in serum from 34 retrospective cases of fluctuating acute renal failure. All subjects had high serum creatinine concentrations caused by renal failure. Apo + holo, holo-TTR-RBP, and (especially) holo-free RBP all correlated poorly but significantly with serum creatinine concentration. Therefore, the use of any form of RBP to measure vitamin A status may be of limited value in subjects with high creatinine concentrations in serum. However, molecular-exclusion HPLC may be able to distinguish increases in RBP concentration associated with renal failure from those caused by altered vitamin A status, because renal failure causes abnormalities in the number and retention times of chromatographic peaks as well as their areas.


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S. Sankaranarayanan, M. Suarez, D. Taren, D. Genaro-Wolf, B. Duncan, K. Shrestha, N. Shrestha, and F. J. Rosales
The Concentration of Free Holo-Retinol Binding Protein Is Higher in Vitamin A-Sufficient than in Deficient Nepalese Women in Late Pregnancy
J. Nutr., December 1, 2005; 135(12): 2817 - 2822.
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