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Clinical Chemistry 36: 677-680, 1990;
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Clinical Chemistry, Vol 36, 677-680, Copyright © 1990 by American Association for Clinical Chemistry

Biological factors affecting concentrations of serum LpAI lipoprotein particles in serum, and determination of reference limits

J Steinmetz, A Choukaife, S Visvikis, J Henny and G Siest
Laboratoire du Centre de Medecine Preventive et Centre du Medicament, URA CNRS 597, Vandoeuvre-les-Nancy, France.

We used an electroimmunoassay to measure LpAI lipoprotein particles (lipoproteins containing apolipoprotein AI but not apolipoprotein AII) in serum of a presumably healthy population of about 1000 subjects, noting sex- and age-related variations for the age interval four to 70 years. Results were higher for women than men. For males, the value for the 50th percentile of the distribution was highest in the 10- to 14- year subgroup, 0.69 g/L, decreasing to 0.60 g/L in adults. For females, the values increased regularly, from 0.59 g/L at ages four to 10 years to 0.79 g/L after age 55 years. The influence of puberty, menopause, oral contraceptives, alcohol consumption, and morphometric characteristics was studied. Only being overweight by more than 20% statistically influenced LpAI values in men and in women. We used these results to select a reference population and to establish reference limits of LpAI at ages 25 to 35 years: 0.40-0.95 g/L for men and 0.46- 1.05 g/L for women.


The following articles in journals at HighWire Press have cited this article:


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 Arterioscler. Thromb. Vasc. Bio.Home page
T. Sakai, V. S. Kamanna, and M. L. Kashyap
Niacin, but Not Gemfibrozil, Selectively Increases LP-AI, a Cardioprotective Subfraction of HDL, in Patients With Low HDL Cholesterol
Arterioscler. Thromb. Vasc. Biol., November 1, 2001; 21(11): 1783 - 1789.
[Abstract] [Full Text] [PDF]


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