Clinical Chemistry
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Clinical Chemistry 36: 772-774, 1990;
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Clinical Chemistry, Vol 36, 772-774, Copyright © 1990 by American Association for Clinical Chemistry

High predictivity of galactosyl-hydroxylysine in urine as an indicator of bone metastases from breast cancer

L Moro, C Gazzarrini, C Modricky, L Rovis, B de Bernard, E Galligioni, D Crivellari, S Morassut and S Monfardini
Dipartimento di Biochimica, Universita degli Studi de Trieste, Italy.

We measured the urinary excretion of galactosyl-hydroxylysine (GH) and hydroxyproline in two groups of women with breast cancer, with (M+, n = 24) and without (Mo, n = 30) clinical, scintigraphic, or radiological evidence of bone metastases. Both these compounds are excreted in larger amounts in the M+ group than in the Mo patients. However, GH, which is a specific marker for bone collagen, provides better predictivity for bone metastases than does hydroxyproline: 92% sensitivity and 90% specificity vs 74% and 79%, respectively, for hydroxyproline.


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 J. Clin. Endocrinol. Metab.Home page
B. Fohr, C. R. Dunstan, and M. J. Seibel
Markers of Bone Remodeling in Metastatic Bone Disease
J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5059 - 5075.
[Abstract] [Full Text] [PDF]


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