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Clinical Chemistry 36: 807-808, 1990;
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Clinical Chemistry, Vol 36, 807-808, Copyright © 1990 by American Association for Clinical Chemistry

Benzalkonium interference with test methods for potassium and sodium

TR Koch and JD Cook
Department of Pathology, University of Maryland School of Medicine, Baltimore 21201.

Six automated instruments that measure sodium and potassium were tested for interference from two compounds used in catheters. Tridodecylmethylammonium heparin did not interfere with any of the methods. However, benzalkonium heparin falsely increased sodium measurement with the Kodak Ektachem, and falsely increased potassium measurements with three instruments (Beckman Astra, Baxter Paramax, and the Instrumentation Laboratory Monarch) in which ion-selective electrodes measure potassium in diluted serum. Three instruments in which ion-selective electrodes measure serum directly--Du Pont Dimension, Abbott Spectrum, and Kodak Ektachem--experienced no interference with potassium measurements. Interference of benzalkonium with potassium measurements may result from its interaction with the electrode membranes, which is accentuated in diluted serum.


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 Clin. Chem.Home page
G. L. Hortin, N. S. Harris, and W. E. Winter
Commentary
Clin. Chem., November 1, 2009; 55(11): 1908 - 1909.
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