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Clinical Chemistry 36: 908-910, 1990;
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Clinical Chemistry, Vol 36, 908-910, Copyright © 1990 by American Association for Clinical Chemistry

Screening for drugs of abuse: effect of heat-treating urine for safe handling of samples [published erratum appears in Clin Chem 1990 Aug;36(8 Pt 1):1530]

K Wolff, MA Shanab, MJ Sanderson and AW Hay
Department of Chemical Pathology, Old Medical School, University of Leeds, U.K.

Heating urine samples from high-risk patients for 1 h at 56 degrees C is no longer believed to completely inactivate human immunodeficiency virus (HIV; AIDS virus). To protect staff who are handling infectious samples such as those from drug-addiction units, heating at a higher temperature may be necessary. We report the stability to heat treatment (at 60, 70, and 100 degrees C) at pH 5.1 and 7.6 of some commonly abused drugs, namely, methadone, pethidine, amphetamine, the cocaine metabolite, benzoylecgonine, and the dextropropoxyphene metabolite nordextropropoxyphene. Heat-treating urine at 60 degrees C for 1.5 h or 70 degrees C for 1 h did not significantly affect the measured concentrations of these drugs. However, heat treatment at 100 degrees C for 1 h reduced the recovery of all the drugs. Benzoylecgonine and amphetamine were most susceptible to the different forms of heat treatment.




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Copyright © 1990 by the American Association for Clinical Chemistry.