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Clinical Chemistry 36: 1346-1350, 1990;
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Clinical Chemistry, Vol 36, 1346-1350, Copyright © 1990 by American Association for Clinical Chemistry

Use and abuse of imprecision profiles: some pitfalls illustrated by computing and plotting confidence intervals

WA Sadler and MH Smith
Department of Nuclear Medicine, Christchurch Hospital, New Zealand.

Published estimates of the imprecision characteristics of immunoassays are often based on quantities of data that seem to be inadequate. The increasing use of imprecision profiles has not necessarily improved the situation. We describe and illustrate a method of computing 95% confidence intervals for profiles estimated directly from replicated assay results. The data used were chosen to mimic the sort of data that are typically available in practice, either within laboratories or from external quality-assessment programs. Use of confidence intervals is an effective pictorial way of incorporating information about the quantity and the distribution of the data used for estimation. This is in keeping with an important property of imprecision profile plots: potentially complex information is summarized in a readily comprehensible way. A computer program is available for estimating and plotting profiles and their 95% confidence intervals.


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