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Clinical Chemistry 36: 1436-1439, 1990;
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Clinical Chemistry, Vol 36, 1436-1439, Copyright © 1990 by American Association for Clinical Chemistry

Determination of cocaine concentrations in plasma by high-performance liquid chromatography [published erratum appears in Clin Chem 1991 Jun;37(6):886]

P Jatlow and H Nadim
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06510.

We describe a procedure for measuring concentrations of cocaine in plasma by reversed-phase high-performance liquid chromatography, with ion-pairing. The procedure involves solvent extraction followed by back- extraction with dilute acid. The n-propyl ester of benzoylecgonine is used as an internal standard. An evaporation step is not required, and concentrations as low as 5 micrograms/L can be quantified. Plasma concentrations of cocaine determined by high-performance liquid chromatography correlated well with those determined by a previously reported gas-chromatographic procedure with nitrogen detection.


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